Oleic- and docosahexaenoic acid-containing phosphatidylethanolamines differentially phase separate from sphingomyelin
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چکیده
منابع مشابه
No differential effect between docosahexaenoic acid and oleic acid in preventing cognitive decline.
Recently, Dangour et al (1) published the results from a randomized clinical trial (RCT) on the effects in participants of a 24-mo supplement intervention with eicosapentaenoic acid (EPA; 200 mg/d) and docosahexaenoic acid (DHA; 500 mg/d) compared with a control group who received an undisclosed amount of olive oil. The main objective of the study was to slow cognitive decline in people aged 70...
متن کاملPhase behavior and domain size in sphingomyelin-containing lipid bilayers.
Membrane raft size measurements are crucial to understanding the stability and functionality of rafts in cells. The challenge of accurately measuring raft size is evidenced by the disparate reports of domain sizes, which range from nanometers to microns for the ternary model membrane system sphingomyelin (SM)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/cholesterol (Chol). Using Förs...
متن کاملComparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein
Interphotoreceptor retinoid-binding protein (IRBP), which binds retinoids and fatty acids, is the major soluble protein in the interphotoreceptor matrix (IPM) but its role remains ambiguous. Using competitive fluorescence and tryptophan-quenching assays we found oleic acid and other cis-monounsaturated fatty acids bind much more strongly than does docosahexaenoic acid to bovine IRBP. IPM's fatt...
متن کاملMetabolism and functions of docosahexaenoic acid‐containing membrane glycerophospholipids
Omega-3 (ω-3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to have important roles in human health and disease. Besides being utilized as fuel, ω-3 FAs have specific functions based on their structural characteristics. These functions include serving as ligands for several receptors, precursors of lipid mediators, and components of membrane glyc...
متن کاملMinoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting
In this work, we examined enhanced skin delivery of minoxidil applied in nanoemulsions incorporating skin penetration enhancers. Aliquots of fully characterized oil-in-water nanoemulsions (1 mL), containing minoxidil (2%) and the skin penetration enhancer oleic acid or eucalyptol as oil phases, were applied to full-thickness excised human skin in Franz diffusion cells, while aqueous solutions (...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2009
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2009.08.019